Novelos Reaches Milestone With Its Hepatitis-C Treatment
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Congratulations are in order for Novelos Therapeutics (OTCBB: NVLT); the company just enrolled its first test patient in its U.S. NOV-205 trial. Novelos’ NOV-205 compound is a promising drug designed to fight hepatitis-C. It showed efficacy against hepatitis-B and C cases in Russian trials, and now the company will seek to confirm its effectiveness as they enter Phase 1b testing in the United States.
If the story seems ‘familiar, but not really’, we’re not surprised…most of the recent Novelos chatter has actually been about NOV-002, which is their company’s lung cancer treatment currently in Phase 3 testing. We haven’t heard much about the hepatitis treatment in the shadow of NOV-002, since the lung cancer treatment is much closer to being brought to the market.
As participants in the global community, we’re excited to see progress being made in the fight against lung cancer as well as hepatitis. Chronic hepatitis-C is estimated to affect 170 million people on a global basis, with 4 million new infections each year. So, the need is clear, and we applaud the work.
That said, being investors, we also see Novelos’ opportunity. We already know the cancer market is roughly worth $10 billion to $20 billion a year, with some estimates being even higher. But, we weren’t aware the hepatitis market is expected to be about $3 billion this year. That’s a big piece of pie, but the mind-boggling part is how fast it’s growing…by 2010, it’s projected to be more than an $8 billion opportunity worldwide.
Of course, the other side of the coin is ‘does it work?’ Although it’s only in Phase 1b testing in the U.S., in other geopolitical regions so far, the results have been good.
In the Russian trials, based on clinical studies in hepatitis-B and C patients, NOV-205 greatly reduced or eliminated hepatitis viral levels 30 days after treatment. It also significantly improved serum biochemical markers of liver damage. This is actually a huge advance when given the specifics of the situation. See, the biggest portion of chronic hepatitis-C (genotype 1) patients don’t respond well, or permanently, to current methods of treatments. Essentially, if they are ‘non-responders’, which half of them are, there is no viable treatment. However, with NOV-205, new alternatives are in the development pipeline.
Our take on Novelos stock? You’ve got to like a company that has more than one way to win (like a lung cancer treatment and a hepatitis treatment). And, you’ve got to like a company that has new stuff to roll out over the next few years (NOV-002 is currently in phase 3, while NOV-205 is on Phase 1). So, sure, NVLT has a lot of potential. We have no doubt things will remain volatile - and perhaps even frustrating at times - for shareholders. Meaningful test results for Phase 1b aren’t expected until early 2007. However, investors should also keep the bigger opportunity in mind, which could take years to fully materialize.
In the meantime, it sure looks like NVLT shares are itching to come up and off those recent new lows. The stock is significantly above the 50 day moving average line for the first time since December. And, clearly something has changed for the better as of Monday, at least to someone big enough to push the shares from 72 cents to 86 cents. That brief flash of bullish may also be an institutional tip-off. We shall see.














